2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140893
    Biotin-PEG6-alcohol 906099-89-6 99.33%
    Biotin-PEG6-alcohol is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG6-alcohol
  • HY-140800
    Azido-PEG9-alcohol 1984776-37-5 99.95%
    Azido-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-alcohol
  • HY-140551
    NH-bis(PEG3-azide) 1258939-39-7 98.0%
    NH-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    NH-bis(PEG3-azide)
  • HY-140825
    Bromoacetamido-PEG3-azide 940005-81-2
    Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromoacetamido-PEG3-azide
  • HY-130887
    (+)-Biotin-SLC 1864003-57-5
    (+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (+)-Biotin-SLC
  • HY-140356
    Tos-PEG6-OH 42749-28-0
    Tos-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG6-OH
  • HY-140559
    N-(Azido-PEG2)-N-Boc-PEG3-NHS ester 2093153-85-4
    N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Boc-PEG3-NHS ester
  • HY-140995
    Bis-Mal-PEG11
    Bis-Mal-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-Mal-PEG11
  • HY-146219
    Biotin-nPEG-amine 604786-74-5 ≥99.0%
    Biotin-nPEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-nPEG-amine
  • HY-129637
    NH2-PEG5-OH 34188-11-9 98.0%
    NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG5-OH
  • HY-W035376
    m-PEG6-CH2CH2CHO 1058691-77-2
    m-PEG6-CH2CH2CHO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-CH2CH2CHO is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG6-CH2CH2CHO
  • HY-138718
    m-PEG14-NHS ester
    m-PEG14-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG14-NHS ester
  • HY-140002
    Amino-PEG1-C2-acid 144942-89-2 98.0%
    Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG1-C2-acid
  • HY-126998
    Bis-PEG4-PFP ester 1314378-12-5
    Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG4-PFP ester
  • HY-133323
    m-PEG24-acid 2248203-61-2 99.91%
    m-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-acid
  • HY-W096067
    Benzyl-PEG7-alcohol 423763-19-3
    Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG7-alcohol
  • HY-140991
    Mal-NH-Boc 134272-63-2
    Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH-Boc
  • HY-140310
    TCO-PEG4-DBCO 1801863-88-6 ≥99.0%
    TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG4-DBCO
  • HY-140271
    DBCO-PEG1-NHS ester 2228857-34-7
    DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG1-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG1-NHS ester
  • HY-140925
    Diazo Biotin-PEG3-alkyne 1884349-58-9 98.07%
    Diazo Biotin-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Diazo Biotin-PEG3-alkyne
PROTAC Linkers Isoform Comparison

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